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You are here:Home » Antibodies » Abs to Enzymes, Transferase » Anti -Factor XIII (Factor-XIII, FXIII, bA525O21.1, Coagulation Factor XIII, Coagulation Factor XIII A Chain, Coagulation Factor XIII A Polypeptide, Coagulation Factor XIII A1 Polypeptide, Coagulation Factor XIII A1 Subunit, Coagulation Factor XIIIa, Factor XIII

Anti -Factor XIII (Factor-XIII, FXIII, bA525O21.1, Coagulation Factor XIII, Coagulation
Factor XIII A Chain, Coagulation Factor XIII A Polypeptide, Coagulation Factor XIII A1
Polypeptide, Coagulation Factor XIII A1 Subunit, Coagulation Factor XIIIa, Factor XIII

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq]
Catalog #F0019-45J
ApplicationsSuitable for use ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32000
Western Blot: 0.05-0.2ug/ml
Optimal dilutions to be determined by the researcher.
Positve ControlHuman Placenta lysates. ~90kDa
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in Tris-saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-HRKLIASMSSDSLRH, from the internal region of the protein. (NP_000120.2)
SpecificityRecognizes human F13A. Species sequence homology: Hu(+) Mu(+).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPlasmatic Transglutaminase 13


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