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You are here:Home » Antibodies » Abs to Coagulation Factors » Anti -Factor XIIIa (Fibrinoligase, Plasma Transglutaminase, Fibrin Stabilizing Factor)

Anti -Factor XIIIa (Fibrinoligase, Plasma Transglutaminase, Fibrin Stabilizing Factor)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH
Factor XIII is a b-globulin found in plasma and is composed of two subunits. Factor XIIIa is the catalytic subunit and is a dimer of MW 160kD. Factor XIII is present in plasma as an a2b2 heterodimer (M.W. 320kD); whereas in platelets, only the a2 unit exists. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIII has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans.
Catalog #F0019-50F
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1-2ug/ml for 2hrs at RT.
Immunohistochemistry (Formalin/paraffin): 1:100 for 20 minutes at RT. No special pretreatment is required for staining of formalin-fixed, paraffin-embedded tissues.
Optimal dilutions to be determined by the researcher.
Positive ControlRecombinant human Factor XIII a-subunit, capillary hemangioma, dermatofibroma, and placenta.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No3F177
HostMouse
SourceHuman
Concentration~0.2mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See F0019-50FX.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to a-subunit of coagulation Factor XIII. Cellular Localization
SpecificityRecognizes human reduced (80kD) and nonreduced (160kD) forms of Factor XIII. Does not recognize human Factor XIII B-chain or human Factor XII.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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