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Abs to Tyrosine Kinases
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Anti -FAK, phosphorylated (Tyr576/Tyr577) (Focal Adhesion Kinase 1, FADK 1, pp125FAK, Protein-tyrosine Kinase 2, PTK2, FAK1)
Anti -FAK, phosphorylated (Tyr576/Tyr577) (Focal Adhesion Kinase 1, FADK 1, pp125FAK,
Protein-tyrosine Kinase 2, PTK2, FAK1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IF |
|
| Focal Adhesion Kinase (FAK) is a 125kD non-receptor protein tyrosine kinase that is a substrate for Src and a key element in growth factor and integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. Tyrosine 861 of FAK is a major Src phosphorylation site that promotes the binding of FAK to the cytoplasmic tail integrins and is also involved in cancer. | | | Catalog # | F0019-54R | | Applications | Suitable for use in Immunofluorescence. Other applications not tested. | | Recommended Dilution | Immunofluorescence: 1:100-1:200 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic phosphopeptide corresponding to human FAK around the phosphorylation site of Tyr576/Tyr577 (S-T-YP-YP-K-A). | | Specificity | Recognizes human FAK when phosphorylated at tyrosine 576/tyrosine 577. Species Crossreactivity: mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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