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Abs to Tyrosine Kinases
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Anti -FAK (Focal Adhesion Associated Protein Tyrosine Kinase, BC3)
Anti -FAK (Focal Adhesion Associated Protein Tyrosine Kinase, BC3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
E B |
|
| Focal adhesion kinase (FAK), with 1074 -amino acid protein (about 118,000 Da), is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. FAK is concentrated at the basal edge of only basal keratinocytes that are actively migrating and rapidly proliferating in repairing burn wounds, and is activated and localized to the focal adhesions of spreading keratinocytes in culture. Thus, it has been postulated that FAK may have an important in vivo role in the re-epithelialization of human wounds. FAK protein tyrosine kinase activity has also been shown to increase in cells stimulated to grow by use of mitogenic neuropeptides or neurotransmitters acting through G protein-coupled receptors. | | | Catalog # | F0019-54T | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:10,000 | | Western Blot: 1:500-1:2000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Clone No | 8A147 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Purity | Purified immunoglobulin | | Immunogen | Ni-NTA purified truncated recombinant FAK expressed in E. coli strain BL21 (DE3) | | Specificity | Recognizes truncated FAK recombinant protein (WB), human FAK recombinant protein (ELISA). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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