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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -FAK, phosphorylated (Tyr397) (Focal Adhesion Associated Protein Tyrosine Kinase, BC3)

Anti -FAK, phosphorylated (Tyr397) (Focal Adhesion Associated Protein Tyrosine Kinase,
BC3)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B
FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. FAK regulation includes phosphorylation at multiple tyrosine and serine residues. Phosphorylation of tyrosine generally is associated with positive regulation and growth promotion, however, dephosphorylation at these sites occurs as cells enter mitosis (M-Phase of the cell cycle). In contrast, serine phosphorylation either remains high or is increased as cells enter mitosis and may play a role in focal adhesion disassembly. Tyrosine 397 is the autophosphorylation site of Focal Adhesion Kinase. The site binds Src family SH2 domains and the p85 subunit of PI3-Kinase.
Catalog #F0019-55G
Applications
Suitable for use in Western Blot. Other applications not tested.
Positive ControlLPS treated RAW 264 lysates.
Recommended DilutionWestern Blot: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10H19
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in APS, BSA 0.09% sodium azide, 50% glycerol.
PurityPurified by ammonium sulfate precipitation.
ImmunogenGenerated from human FAK, a.a.393-404, phosphorylated on Tyr397.
SpecificityRecognizes human Focal Adhesion Kinase (FAK), phosphorylated at (Tyr397). Species Crossreactiviy: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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