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You are here:Home » Antibodies » Abs to Protein Kinase Substrates » Anti -FAK phosphorylated (Tyr407) (Focal Adhesion Associated Protein Tyrosine Kinase 1)

Anti -FAK phosphorylated (Tyr407) (Focal Adhesion Associated Protein Tyrosine Kinase 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Focal Adhesion Kinase (FAK) is a 125kD non-receptor protein tyrosine kinase that was discovered as a substrate for Src and is a key element of integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. Phosphorylation of tyrosine 407 is activated by TGFb and Epithelial Mesenchyme Transition (EMT). Unlike other sites on FAK, tyrosine 407 is EGFR independent.
Catalog #F0019-55K
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: A 1:1000 detected FAK phosphorylated on residue Tyr407 in lysate from FAK transfected CEF cells grown on fibronectin.
Optimal dilution to be determined by researcher.
Recommended Secondary Antibodies I1904-39 IgG, X-Adsorbed (HRP) Pab Gt xRb
I1904-40A: IgG, H&L, X-Adsorbed (HRP) Pab Gt xRb
I1904-46Q: IgG, H&L (HRP) Pab Gt xRb
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSuplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.3, 1mg/mL BSA (IgG, protease free), 0.05% sodium azide, 50% glycerol.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to amino acid region encompassing the human, mouse, rat, and chicken phospho-FAK (Tyr407). Species Sequence Homology: mouse, rat and chicken.
SpecificityRecognizes human phospho-FAK (Tyr407), Mr 125kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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