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Anti -FAK, phosphorylated (Tyr861) (Focal Adhesion Associated Protein Tyrosine Kinase, BC3)
Anti -FAK, phosphorylated (Tyr861) (Focal Adhesion Associated Protein Tyrosine Kinase,
BC3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| Focal Adhesion Kinase (FAK) is a 125kD non-receptor protein tyrosine kinase that is a substrate for Src and a key element in growth factor and integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. Tyrosine 861 of FAK is a major Src phosphorylation site that promotes the binding of FAK to the cytoplasmic tail integrins and is also involved in cancer. | | | Catalog # | F0019-56J | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Optimal dilution determined by the researcher. | | Positive Control | Chicken embryo fibroblasts expressing FAK protein and plated on fibronectin. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in Dulbecco’s PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic phosphopeptide derived from the region of human FAK that contains tyrosine 861. | | Specificity | Recognizes human FAK when phosphorylated at Tyr861, at ~125kD.. Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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