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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -FAK, phosphorylated (Tyr861) (Focal Adhesion Associated Protein Tyrosine Kinase, BC3)

Anti -FAK, phosphorylated (Tyr861) (Focal Adhesion Associated Protein Tyrosine Kinase,
BC3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Focal Adhesion Kinase (FAK) is a 125kD non-receptor protein tyrosine kinase that is a substrate for Src and a key element in growth factor and integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. Tyrosine 861 of FAK is a major Src phosphorylation site that promotes the binding of FAK to the cytoplasmic tail integrins and is also involved in cancer.
Catalog #F0019-56J
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilution determined by the researcher.
Positive ControlChicken embryo fibroblasts expressing FAK protein and plated on fibronectin.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in Dulbecco’s PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol.
PurityPurified by affinity chromatography.
ImmunogenSynthetic phosphopeptide derived from the region of human FAK that contains tyrosine 861.
SpecificityRecognizes human FAK when phosphorylated at Tyr861, at ~125kD.. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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