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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -FAK, phosphorylated (Tyr861) (Focal Adhesion Associated Protein Tyrosine Kinase, Focal Adhesion Kinase, FADK, Focal Adhesion Kinase 1, FADK 1, FAK1, BC3, FRNK, pp125FAK, Protein Tyrosine Kinase 2, PTK2)

Anti -FAK, phosphorylated (Tyr861) (Focal Adhesion Associated Protein Tyrosine Kinase,
Focal Adhesion Kinase, FADK, Focal Adhesion Kinase 1, FADK 1, FAK1, BC3, FRNK, pp125FAK,
Protein Tyrosine Kinase 2, PTK2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
FAK is a cytoplasmic non-receptor protein-tyrosine kinase found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents and is involved in signaling pathways involved in cell motility, proliferation, and apoptosis. It is activated by tyrosine phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. FAK plays a potential role in oncogenic transformation resulting in increased kinase activity. Human FAK gene is localized on chromosomal region 8q24-qter.
Catalog #F0019-57Q
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human FAK around the phosphorylation site of tyrosine 861 (H-I-YP-Q-P).
SpecificityRecognizes human FAK, phosphorylated at Tyr861. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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