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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -FAK (Focal Adhesion Associated Protein Tyrosine Kinase, BC3)

Anti -FAK (Focal Adhesion Associated Protein Tyrosine Kinase, BC3)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites B IP
FAK is a 125 Kd protein that is recruited as a participant in focal adhesion dynamics between cells and has a role in motility and cell survival. FAK is a highly conserved, non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein tyrosine kinase v-src (Guan, J L and Shalloway, D). This cytosolic kinase has been implicated in diverse cellular roles including cell locomotion, mitogen response and cell survival. FAK is typically located at structures known as focal adhesions, these are multi-protein structures that link the extracellular matrix (ECM) to the cytoplasmic cytoskeleton. Additional components of focal adhesions include actin, filamin, vinculin, talin, paxillin and tensin (Burridge, K, et al).
Catalog #F0019-58P
Applications
Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 0.2ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHEK293 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10H11
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.05% sodium azide.
PurityAscites
ImmunogenRecombinant corresponding to aa103-553 to region of chicken FAK.
SpecificityRecognizes human Focal Adhesion Kinase. Species Crossreactivity: mouse, rat, chicken.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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