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You are here:Home » Antibodies » Abs to Fanconi Proteins » Anti -Fanconi anemia C (FANCC, FA3, FAC, FACC, bA80I15.1, FLJ14675)

Anti -Fanconi anemia C (FANCC, FA3, FAC, FACC, bA80I15.1, FLJ14675)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
The members of the Fanconi anemia complementation group do not share sequence similarity but are related by their assembly into a common nuclear protein complex.
Catalog #F0019-58V7B
FANCC is involved in DNA repair and maybe involved in maintenance of normal chromosome stability and inter-strand DNA cross link repair.
Mutations in the FANCC gene are a cause of Fanconi anemia (FA), a genetically heterogeneous recessive disorder characterized by progressive pancytopenia, susceptibly to malignancies, cytogenetic instability, hypersensitivity to DNA damaging agents and defective DNA repair. FANC complexes are not found in individuals with FA.
ApplicationsSuitable for use in ELISA, Immunohistochemistry (paraffin), and Western Blot. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 2.5ug/ml
ELISA: 1:20,000-1:80,000
Western Blot: 1:1000-1:3000
Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections.
Optimal dilutions to be determined by the researcher.
Positive Control Human brain (cortex)
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa sequence 96-112 of human FANCC.
SpecificityRecognizes human FANCC. Species Crossreactivity: chimpanzee.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesFanconi anemia Complementation Group C, Fanconi anemia Group C Protein, Protein FACC


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