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You are here:Home » Antibodies » Abs to Fanconi Proteins » Anti -Fanconi anemia F (FANCF, FAF, MGC126856, Protein FACF)

Anti -Fanconi anemia F (FANCF, FAF, MGC126856, Protein FACF)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E IH
Research indicates that FANCF is involved in DNA repair, either with post-replication repair or a cell cycle checkpoint function. FANCF has also been implicated in inter-strand DNA cross-link repair and in the maintenance of normal chromosome stability.
Catalog #F0019-58W4B
Defects in FANCF are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level, it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
ApplicationsSuitable for use in ELISA and Immunohistochemistry (paraffin). Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 2.5ug/ml
ELISA: 1:15,000-1:60,000
Requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Optimal dilutions to be determined by the researcher.
Positive Control Human kidney
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide corresponding to an internal aa sequence of human FANCF.
SpecificityRecognizes human FANCF. Species Crossreactivity: chimpanzee.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesFanconi anemia Complementation Group F, Fanconi anemia Group F Protein


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