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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -FBG2 (F-box Only Protein 6, F-box Protein that Recognizes Sugar Chains 2, F-box/G-domain Protein 2, FBXO6, FBS2, FBX6)

Anti -FBG2 (F-box Only Protein 6, F-box Protein that Recognizes Sugar Chains 2,
F-box/G-domain Protein 2, FBXO6, FBS2, FBX6)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
Catalog #F0023-87A
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:8000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-EAAQSPYRAVVQIF, from FBXO6, at C-terminal (NP_060908.1).
SpecificityRecognizes FBXO6. Species sequence homology: Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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