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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -FBXW7 (F-box and WD Repeat Domain Containing 7, F-box/WD Repeat-containing Protein 7, FBW7, Archipelago Homolog, AGO, hAgo, CDC4, hCdc4, F-box and WD-40 Domain-containing Protein 7, F-box Protein FBX30, FBX30, FBXO30, FBXW6, FBW6, SEL10, SEL-10)

Anti -FBXW7 (F-box and WD Repeat Domain Containing 7, F-box/WD Repeat-containing Protein
7, FBW7, Archipelago Homolog, AGO, hAgo, CDC4, hCdc4, F-box and WD-40 Domain-containing
Protein 7, F-box Protein FBX30, FBX30, FBXO30, FBXW6, FBW6, SEL10, SEL-10)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Catalog #F0024-77D1
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No3D1
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant corresponding to aa599-708 from human FBXW7 with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human FBXW7.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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