Anti -FBXW7 (F-box and WD Repeat Domain Containing 7, F-box/WD Repeat-containing Protein
7, FBW7, Archipelago Homolog, AGO, hAgo, CDC4, hCdc4, F-box and WD-40 Domain-containing
Protein 7, F-box Protein FBX30, FBX30, FBXO30, FBXW6, FBW6, SEL10, SEL-10)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
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| The F-box protein family is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins are divided into 3 classes: FBWs containing WD-40 domains, FBLs containing leucine-rich repeats, and FBXs containing either different protein-protein interaction modules or no recognizable motifs. They constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. Cdc4 is one member of this family, which is also known as AGO, FBW7, FBX30 or SEL10. CDC4 binds directly to cyclin E and targets cyclin E for ubiquitin-mediated degradation. Cdc4 proteins of amino acid lengths varying from 553aa to 707aa in length have been reported. Cdc4 is an inhibitor of Notch signaling that targets Notch for ubiquitin-mediated degradation after a nuclear phosphorylation event. Cdc4 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production. Thus, it may be important for Alzheimer's disease. Mutations of the CDC4 gene are detected in ovarian and breast cancer cell lines and the CDC4 gene may also be involved in the pathogenesis of human pancreatic and endometrial cancers. | | | Catalog # | F0024-77E | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa1-11 (MCVPRSGLILS) of human Cdc4, GenBank no. NP_060785.2. | | Specificity | Recognizes human Cdc4, 69kD isoform. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | DKFZp686F23254, FLJ16457 |
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Download Specifications for Anti -FBXW7 (F-box and WD Repeat Domain Containing 7, F-box/WD Repeat-containing Protein 7, FBW7, Archipelago Homolog, AGO, hAgo, CDC4, hCdc4, F-box and WD-40 Domain-containing Protein 7, F-box Protein FBX30, FBX30, FBXO30, FBXW6, FBW6, SEL10, SEL-10) |
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