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F0025-79B Mouse Anti-FcRL6 (Fc Receptor-like Protein 6, FcR-like Protein 6, Fc Receptor Homolog 6, IFGP6, FCRH6)

Specifications
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
Q6DN72
Isotype
IgG1
Clone Number
12K96
Grade
Affinity Purified
Applications
FC
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

FCRL6 (Fc receptor-like protein 6; also FcRH6 and IFGP6) is a 66kD member of the Ig Superfamily. It is found on CD56dim CD16+ NK cells, CD56+ CD3+ NKT cells, gd T cells, and effector plus effector-memory CD8+ T cells. FCRL6 is not a receptor for immunoglobulin. It does, however, bind to isoforms of HLA-DR that are expressed on APCs. Given that FCRL6 contains a cytoplasmic ITIM, FCRL6 may function as an inhibitory receptor for MHC Class II. Mature human FCRL6 is a 415aa type I transmembrane protein. It contains a 288aa extracellular region aa20-307 that shows three C2-type Ig-like domains aa20-293, and a 106aa cytoplasmic domain. There are multiple potential splice variants. One shows a deletion of aa105-200 accompanied by a 13aa substitution for aa394-434; a second possesses a 15aa substitution for aa383-434; and a third shows an alternative start site seven aa upstream of the standard site accompanied by a 13aa substitution for aa394-434. Over aa16-312, human FCRL6 shares only 33% aa identity with the mouse counterpart to FCRL6.

Applications
Suitable for use in Flow Cytometry. Other applications not tested.
Recommended Dilution
Flow Cytometry: 2.5ug labels 10e6 cells Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Recombinant corresponding to aa16-312 from human FCRL6 expressed in CHO cell line.
Form
Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
Purity
Purified by Protein A/G affinity chromatography.
Specificity
Recognizes human FCRL6. Does not react with recombinant human FCRL1, rhFCRL2, rhFCRL3, rhFCRL4, rhFCRL5, rhFcRN, or rhFCRLB/FCRY.
Conjugates
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