FCRL6 (Fc receptor-like protein 6; also FcRH6 and IFGP6) is a 66kD member of the Ig Superfamily. It is found on CD56dim CD16+ NK cells, CD56+ CD3+ NKT cells, gd T cells, and effector plus effector-memory CD8+ T cells. FCRL6 is not a receptor for immunoglobulin. It does, however, bind to isoforms of HLA-DR that are expressed on APCs. Given that FCRL6 contains a cytoplasmic ITIM, FCRL6 may function as an inhibitory receptor for MHC Class II. Mature human FCRL6 is a 415aa type I transmembrane protein. It contains a 288aa extracellular region aa20-307 that shows three C2-type Ig-like domains aa20-293, and a 106aa cytoplasmic domain. There are multiple potential splice variants. One shows a deletion of aa105-200 accompanied by a 13aa substitution for aa394-434; a second possesses a 15aa substitution for aa383-434; and a third shows an alternative start site seven aa upstream of the standard site accompanied by a 13aa substitution for aa394-434. Over aa16-312, human FCRL6 shares only 33% aa identity with the mouse counterpart to FCRL6.
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