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You are here:Home » Antibodies » Abs to Enzymes, Endonuclease » Anti -Fen1 (FEN-1, Flap Structure-specific Endonuclease 1, MF1, Maturation Factor-1, RAD2, DNase IV)

Anti -Fen1 (FEN-1, Flap Structure-specific Endonuclease 1, MF1, Maturation Factor-1, RAD2,
DNase IV)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
FEN-1 (Flap Endonuclease and Five prime Exonuclease) is a 42kD protein that functions as an endonuclease that cleaves branched DNA structures containing single-stranded 5' flaps or as an exonuclease on DNA nicks and gaps. FEN-1 endonuclease and exonuclease activities are stimulated by an association with proliferating cell nuclear antigen (PCNA) in the nucleus. FEN-1 is believed to have important roles in DNA replication and repair and is required in cell-free DNA replication systems.
Catalog #F0047-03
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormAs reported
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide, which represented a portion of human Flap Structure-specific Endonuclease 1 encoded within exon 2 (LocusLink ID 2237). The peptide is derived from a portion of FEN-1 that begins a few residues downstream from the I-domain as defined in Swiss-Prot entry P39748.
SpecificitySpecific for human FEN-1 protein. Other species have not been tested. Mouse and rat FEN-1 have 1 mismatch with the peptide used as the immunogen.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesFlap endonuclease 1


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