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You are here:Home » Antibodies » Abs to Enzymes, Reductase » Anti -FDXR (NADPH:adrenodoxin Oxidoreductase, Mitochondrial, AR, Adrenodoxin Reductase, Ferredoxin-NADP(+) Reductase, Ferredoxin Reductase, ADXR)

Anti -FDXR (NADPH:adrenodoxin Oxidoreductase, Mitochondrial, AR, Adrenodoxin Reductase,
Ferredoxin-NADP(+) Reductase, Ferredoxin Reductase, ADXR)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP
Ferredoxin reductase is a ubiquitous flavoenzyme, containing noncovalently bound FAD as a prosthetic group. It plays a role in delivering NADPH or low potential one-electron donors such as ferredoxin and flavodoxin to redox-based metabolisms in plastids, mitochondria and bacteria. In mammals, ferredoxin reductase is loosely associated with the inner mitochondrial membrane and receives electrons from NADPH. These electrons are transferred to ferredoxin which shuttles electrons to cytochrome P450 in the adrenal cortex mitochondrial steroid hydroxylation systems. Function serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Catalog #F3981-01A
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:3000
Immunoprecipitation: 1ul
Optimal dilutions to be determined by the researcher.
Positive ControlHeLa cells
Cellular LocalizationMitochondrion matrix
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in HEPES, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol.
PuritySerum
ImmunogenRecombinant corresponding to human Ferredoxin Reductase fragment expressed in E.coli.
SpecificityRecognizes human Ferredoxin Reductase. Species Crossreactivity: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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