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Specifications

Clone Host Grade Applications Polyclonal Goat Affinity Purified E

Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and soluble form. It forms a holoenzyme of ~450kD, consisting of 24 subunits of two types, H (heavy; 21kD) and L (light; 19kD), and is capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiological status of the cell, the ratio of H to L subunits in ferritin can vary widely. Ferritin is found in the liver, spleen, kidney and heart, with smaller amounts being found in blood. Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia, and is also used as a marker for restless leg syndrome, hemochromatosis and porphyria. As ferritin is an acute-phase reactant, it is often elevated during infection. Defects in ferritin proteins are associated with several neurodegenerative diseases.
Catalog #	F4015-17
Applications	Suitable for use in ELISA, Radiolabeling and Enzyme conjugation. Other applications not tested.
Recommended Dilutions	ELISA: Can be matched with F4015
	Optimal dilutions to be determined by the researcher.
Affinity Constant	3x10e10L/mole
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Goat
Source	Human
Concentration	~5mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
Purity	Purified by affinity chromatography.
Immunogen	Affinity pure ferritin from human liver
Specificity	Recognizes human liver and spleen ferritin (100%). Very little crossreactivity to human heart ferritin (<1%)
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.