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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -Fetuin (alpha-2 Heremans-Schmid Glycoprotein, FHSG, Fetuin A)

Anti -Fetuin (alpha-2 Heremans-Schmid Glycoprotein, FHSG, Fetuin A)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Fetuin is a 59kD glycoprotein consisting of two cystatin-like domains and a smaller unrelated domain, is predominantly synthesized in liver. It is secreted into the blood stream and deposited as a noncollagenous protein in mineralized bones and teeth. Fetuin occurs in high serum concentrations during fetal life, whereas its level declines following infection, inflamation and malignancy. Fetuin acts as an important circulating inhibitor of ectopic calcification, a frequent complication of many degenerative diseases. Low serum level of Fetuin is associated with vascular and valvular calcification, atherosclerosis, malnutrition and higher cardiovascular mortality in chronic renal failure, liver cancer and liver cirrhosis patients on long-term dialysis. AHSG protein represents a natural inhibitor of tyrosinase kinase activity of the insulin receptor. It may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation. The serum and bone-resident Fetuin binds to transforming growth factor-b and blocks TGF-b binding to cell surface receptors.
Catalog #F4102-04
ApplicationsSuitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications have not been tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder from PBS, pH 7.2. Preservative free. Reconstitute in 100ul of sterile ddH2O. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
PurityPurified by immunoaffinity chromatography.
ImmunogenHuman fetuin
SpecificityRecognizes human fetuin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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