Anti -Fkbp8 (Peptidyl-prolyl Cis-trans Isomerase FKBP8, PPIase FKBP8, 38kD FK506-binding
Protein, 38kD FKBP, FKBP-38, mFKBP38, FK506-binding Protein 8, FKBP-8, FKBPR38, Rotamase,
Fkbp38, Sam11)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
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| FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes. | | | Catalog # | F4150-20C | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-4ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 0.1% BSA, 0.02% thimerosal, 20% glycerol. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa344 from mouse FKBP38. | | Specificity | Recognizes mouse FKBP38 at ~40kD. Species Crossreactivity: human and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Fkbp8 (Peptidyl-prolyl Cis-trans Isomerase FKBP8, PPIase FKBP8, 38kD FK506-binding Protein, 38kD FKBP, FKBP-38, mFKBP38, FK506-binding Protein 8, FKBP-8, FKBPR38, Rotamase, Fkbp38, Sam11) |
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