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You are here:Home » Antibodies » Abs to Binding Proteins » Anti -Fkbp8 (Peptidyl-prolyl Cis-trans Isomerase FKBP8, PPIase FKBP8, 38kD FK506-binding Protein, 38kD FKBP, FKBP-38, mFKBP38, FK506-binding Protein 8, FKBP-8, FKBPR38, Rotamase, Fkbp38, Sam11)

Anti -Fkbp8 (Peptidyl-prolyl Cis-trans Isomerase FKBP8, PPIase FKBP8, 38kD FK506-binding
Protein, 38kD FKBP, FKBP-38, mFKBP38, FK506-binding Protein 8, FKBP-8, FKBPR38, Rotamase,
Fkbp38, Sam11)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.
Catalog #F4150-20C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% thimerosal, 20% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa344 from mouse FKBP38.
SpecificityRecognizes mouse FKBP38 at ~40kD. Species Crossreactivity: human and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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