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You are here:Home » Molecular Biology » MB-Binding Proteins » FKBP1a /FKBP12, 1-108aa, Recombinant, Human (FK506 binding protein 1a, 12kD, PPIase FKBP1A, Rotamase, FKBP1, PKC12)

FKBP1a /FKBP12, 1-108aa, Recombinant, Human (FK506 binding protein 1a, 12kD, PPIase
FKBP1A, Rotamase, FKBP1, PKC12)

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Specifications

FK506 binding protein 1a, also known as FKBP12, belongs to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. Recombinant human FKBP12, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Catalog #F4150-30A
Molecular Weight 14.1kD (128aa)
Endotoxin Level 1.0 EU per 1 ug of protein (determined by LAL method).
AA SequenceMGSSHHHHHH SSGLVPRGSH MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG
QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight14.1kD
SourceE. coli
PurityPurified. 95% by SDS-PAGE.
Concentration~1mg/ml
FormSupplied as a liquid in Tris-HCL, pH 8.0, 100mM sodium chloride, 1mM DTT, 10% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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