FKBP1a /FKBP12, 1-108aa, Recombinant, Human (FK506 binding protein 1a, 12kD, PPIase
FKBP1A, Rotamase, FKBP1, PKC12)
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| FK506 binding protein 1a, also known as FKBP12, belongs to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. Recombinant human FKBP12, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. | | | Catalog # | F4150-30A | | Molecular Weight | 14.1kD (128aa) | | Endotoxin Level | 1.0 EU per 1 ug of protein (determined by LAL method). | | AA Sequence | MGSSHHHHHH SSGLVPRGSH MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG | | QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Molecular Weight | 14.1kD | | Source | E. coli | | Purity | Purified. 95% by SDS-PAGE. | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in Tris-HCL, pH 8.0, 100mM sodium chloride, 1mM DTT, 10% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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