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You are here:Home » Antibodies » Abs to Fibrillin » Anti -Fibrillin 1

Anti -Fibrillin 1

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B IP
Fibrillin-1 is an extracellular acidic protein with a high cysteine content and an extended thread-like shape with mosaic composition of different types of extracellular modules. Most of the fibrillin molecule is contributed by 47 epidermal growth factor-like (EGF-like) repeats; 43 of them have a consensus sequence for calcium binding (cb). Other modules including 8-cysteine motifs (seven), hybrid motifs (two), and unique domains (three) are interspersed throughout the molecule. Fibrillin-1 contains a proline-rich region close to the N-terminus that is replaced by a glycine-rich region in fibrillin-2. The fibrillins are found throughout the connective tissue as integral components of extended fibrils. There is an aberrant expression of fibrillin-1 in Marfan syndrome.
Catalog #F4194
Applications Suitable for use in Immunoblot, Immunoprecipitation, ELISA.
Storage and Handling Maintain at-20ºC in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No2Q629
HostMouse
SourceBovine
ConcentrationNot determined
FormAscites
PurityAscites
ImmunogenBovine zonular fibrils
SpecificityBovine zonular fibrils. Reacts well with human elastin microfibrils and can be used to investigate the presence and organization of these fibrils either in Marfan patients or in fibroblasts obtained from these patients.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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