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You are here:Home » Antibodies » Abs to Fibrillin » Anti -Fibrillin 1

Anti -Fibrillin 1

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH IF
Fibrillin 1 is an extracellular acidic protein with a high cysteine content and an extended thread-like shape with mosaic composition of different types of extracellular modules. Most of the fibrillin molecule is contributed by 47 epidermal growth factor-like (EGF-like) repeats; 43 of them have a consensus sequence for calcium binding (cb). Other modules including 8-cysteine motifs (seven), hybrid motifs (two), and unique domains (three) are interspersed throughout the molecule[3-7]. Fibrillin 1 contains a proline-rich region close to the N-terminus that is replaced by a glycine-rich region in Fibrillin 2. The fibrillins are found throughout the connective tissue as integral components of extended fibrils.
Catalog #F4195-03
Cellular Localization Extracellular microfibrils.
Positive Control Normal skin fibroblasts.
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunohistochemistry (Fr). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No8k192
HostMouse
SourceBovine
Concentration~0.2mg/ml
Form10mM PBS, pH7.4, 0.2%BSA
PurityPurified by Protein G affinity chromatography.
ImmunogenMicrofibrils from zonular apparatus of bovine eye. Epitope: Amino acids 451 - 909.
SpecificitySpecies Crossreactivity: Crossreacts with Human and bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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