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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B IH IF

Fibrillin 1 is an extracellular acidic protein with a high cysteine content and an extended thread-like shape with mosaic composition of different types of extracellular modules. Most of the fibrillin molecule is contributed by 47 epidermal growth factor-like (EGF-like) repeats; 43 of them have a consensus sequence for calcium binding (cb). Other modules including 8-cysteine motifs (seven), hybrid motifs (two), and unique domains (three) are interspersed throughout the molecule[3-7]. Fibrillin 1 contains a proline-rich region close to the N-terminus that is replaced by a glycine-rich region in Fibrillin 2. The fibrillins are found throughout the connective tissue as integral components of extended fibrils.
Catalog #	F4195-03
Cellular Localization	Extracellular microfibrils.
Positive Control	Normal skin fibroblasts.
Applications	Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry (Fr). Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1,k
Clone No	8k192
Host	Mouse
Source	Bovine
Concentration	~0.2mg/ml
Form	10mM PBS, pH7.4, 0.2%BSA
Purity	Purified by Protein G affinity chromatography.
Immunogen	Microfibrils from zonular apparatus of bovine eye. Epitope: Amino acids 451 - 909.
Specificity	Species Crossreactivity: Crossreacts with Human and bovine.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.