Anti -Fibrinogen, Citrullinated (FGA, FGB, FGG, Fibrinogen A alpha Polypeptide Chain,
Fibrinogen alpha Chain, Fibrinogen beta Chain, Fibrinogen gamma Chain, MGC104327,
MGC119422, MGC119423, MGC119425, MGC120405)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E |
|
| Fibrinogen is a protein produced by the liver which helps stop bleeding by helping blood clots to form. Fibrinogen gets deiminated (conversion from arginin to citrullin) by Peptidyl Arginine Deïminase (PAD) in inflamed joints in patients that develop rheumatoid arthritis. Citrulline, while being an amino acid, is not built into proteins during protein synthesis, as it is not coded for by DNA, yet several proteins are known to contain citrulline. Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, while other proteins, like fibrin and vimentin can get deiminated during cell death and tissue inflammation. Patients with rheumatoid arthritis often (at least 80% of them) develop an immune response against proteins containing citrulline. Although the origin of this immune response is not known, detection of antibodies reactive with citrulline containing proteins or peptides is now becoming an important help in the diagnosis of rheumatoid arthritis. | | | Catalog # | F4203-03A | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilutions | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS or Tris-HCl. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 20B2 | | Host | Mouse | | Source | Mouse | | Concentration | ~0.5mg/ml | | Form | Supplied as a lyophilized powder from 10mM ammonium bicarbonate, 1% BSA. Reconstitute with 200ul sterile PBS or Tris-HCl, pH 7-8. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Deiminated mouse fibrinogen peptide. | | Specificity | Recognizes mouse deiminated fibrinogen. Species Crossreactivity: human | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | FGA, FGB, FGG, Fibrinogen A alpha Polypeptide Chain, Fibrinogen alpha Chain, Fibrinogen beta Chain, Fibrinogen gamma Chain, MGC104327, MGC119422, MGC119423, MGC119425, MGC120405 |
|
|
Questions or comments about this product? Inquire here. |
|
|
Download Specifications for Anti -Fibrinogen, Citrullinated (FGA, FGB, FGG, Fibrinogen A alpha Polypeptide Chain, Fibrinogen alpha Chain, Fibrinogen beta Chain, Fibrinogen gamma Chain, MGC104327, MGC119422, MGC119423, MGC119425, MGC120405) |
External Links
|
