| Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. |
|
| Catalog # | F4204-05 |
| Applications | Suitable for use in ELISA and Western Blot. Other applications have not been tested. |
| Recommended Dilutions | |
| Peptide ELISA Titer: 1:16,000 |
| Western Blot: 0.1-0.3ug/ml detects an~ 35kD band observed in Human Liver lysates (calculated MW of 36.4kD according to NP_004458.3). |
| Optimal dilutions to be determined by the researcher. |
| Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
| CAS Number | n/a |
| Clone Type | Polyclonal |
| Isotype | IgG |
| Host | Goat |
| Source | Human |
| Concentration | ~0.5mg/ml |
| Form | Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide. |
| Purity | Purified by peptide affinity chromatography. |
| Immunogen | Synthetic peptide corresponding to C-ETRVKQQQVKIKQ, from the internal region of human FGL1 (NP_004458.3). |
| Specificity | Recognizes human FGL1. Species sequence homology: mouse, rat, canine, bovine. |
|
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
| Alternate names | hepatocyte-derived fibrinogen-related protein 1, hepatocellular carcinoma-related sequence, hepassocin, OTTHUMP00000122468, MGC12455, LFIRE1, HP-041, HFREP1, fibrinogen-like 1, FGL1 |
