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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -Fibroblast Activation Protein alpha (FAPa, FAP, 170kD Melanoma Membrane-bound Gelatinase, DKFZP686G13158, DPPIV, EC 3.4.21.-, Integral Membrane Serine Protease, Seprase)

Anti -Fibroblast Activation Protein alpha (FAPa, FAP, 170kD Melanoma Membrane-bound
Gelatinase, DKFZP686G13158, DPPIV, EC 3.4.21.-, Integral Membrane Serine Protease,
Seprase)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
FAP alpha a type II membrane protein belonging to the serine protease family. FAP alpha is upregulated on activated fibroblasts in response to wounding, and may also be involved in epithelial-mesenchymal interactions during development and tissue repair. Active FAP alpha is a 170kD homodimeric protein which can also exist as a soluble form. FAP alpha can also form heterodimeric complexes with CD26 (DPP4), and these proteins may function co-ordinately to modulate the growth, differentiation, adhesion and metastasis of tumor cells.
Catalog #F4208-57G
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Paraffin): 10ug/ml. Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended.
Optimal dilutions to be determined by the researcher.
Positive ControlUterus
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to the extracellular domain of human FAP alpha, conjugated to KLH.
SpecificityRecognizes human FAP, alpha.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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