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You are here:Home » Molecular Biology » Growth Factors-FGF » Fibroblast Growth Factor, Basic, Recombinant, Mouse (FGFb)

Fibroblast Growth Factor, Basic, Recombinant, Mouse (FGFb)

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Specifications

Mouse FGF basic is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of angiogenesis. Several different forms of the protein exist ranging from 18-24kD in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FGF-1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor.Other homologous FGF belonging to the same family are int-2 (FGF-3), FGF-5, FGF-6, K-FGF and KGF (keratinocyte growth factor =FGF-7 ). All factors are products of different genes, some of which are Oncogene products (FGF-3, FGF-4, FGF-5).
Catalog #F4210-20G
Biological Activity The ED50, calculated by the dose-dependent proliferation of BALB/3T3 cells is <0.5ng/ml.
AA SequenceMPALPEDGGA AFPPGHFKDP KRLYCKNGGF FLRIHPDGRV DGVREKSDPH VKLQLQAEER GVVSIKGVCA NRYLAMKEDG RLLASKCVTE ECFFFERLES NNYNTYRSRK YSSWYVALKR TGQYKLGSKT GPGQKAILFL PMSAKS
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight16.3kD
SourceE. coli
Purity95% as determined by RP-HPLC; Reducing and non-reducing SDS-PAGE. Endotoxin: 1EU/ug(LAL)
FormSupplied as a lyophilized powder. Reconstitute with sterile dH2O, 0.1% BSA or HSA to 0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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