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You are here:Home » Growth Factors, Cytokines » Growth Factors-FGF » Fibroblast Growth Factor 8, Recombinant, Human (FGF8)

Fibroblast Growth Factor 8, Recombinant, Human (FGF8)

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Specifications

Fibroblast Growth Factor-8 (FGF-8b) is a heparin binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8: FGF8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF8 A and B are identical. Human and murine FGF8 E and F are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant human FGF-8b is a 22.4kD protein consisting of 193 amino acid residues.
Catalog #F4211-50
Storage and StabilityLyophilized powder may be stored at -20°C . Reconstitute with 10mM Tris, pH 8.0, 75mM sodium chloride, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Country of Origin USA
Molecular Weight22.4kD
SourceRecombinant, Human (E. coli)
Purity95% by SDS-PAGE and HPLC. Endotoxin: 0.1ng/ug (1EU/ug).
FormSupplied as a lyophilized powder from 10mM Tris, pH 8.0, 75mM sodium chloride. Reconstitute in 10 mM Tris, pH 8.0.
SpecificityBiological Activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is 0.5ng/ml, corresponding to a speci c activity of 2 x 10e6u/mg
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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