Fibroblast Growth Factor 12, Recombinant, Human (FGF12, Fibroblast Growth Factor
Homologous Factor 1, FHF1, Myocyte Activating Factor, FGF12B)
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| FGF12 (Fibroblast growth factor 12) is a member of the FGF superfamily of molecules which currently stands at 22 members. The FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF12 binds to IB2 (islet brain-2), a cellular kinase scaffold, and voltage gated sodium channels and also plays an important role in intracellular signaling and ion exchange. | | | Catalog # | F4212-15B | | Recombinant human FGF12 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. | | Source | Recombinant corresponding to aa1-181 of human FGF12 (His-tagged) expressed in E.coli. | | AA Sequence | MGSSHHHHHH SSGLVPRGSH MESKEPQLKG IVTRLFSQQG YFLQMHPDGT IDGTKDENSD YTLFNLIPVG LRVVAIQGVK | | ASLYVAMNGE GYLYSSDVFT PECKFKESVF ENYYVIYSST LYRQQESGRA WFLGLNKEGQ IMKGNRVKKT KPSSHFVPKP | | IEVCMYREQS LHEIGEKQGR SRKSSGTPTM NGGKVVNQDS T | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 3ug/ml 15% SDS-PAGE, | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. | | Molecular Weight | ~22.6kD | | Source | E. coli | | Purity | Purified 90% by SDS-PAGE. | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 20mM tris pH 7.5, 10% glycerol, 1mM DTT, 2mM EDTA. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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