You are here:Home
»
Growth Factors, Cytokines
»
Growth Factors-FGF
»
Fibroblast growth factor 21, aa29-209, Recombinant, Human (FGF-21)
Fibroblast growth factor 21, aa29-209, Recombinant, Human (FGF-21)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| FGF-21 is a unique member of FGF super family that is reported to be primarily produced by the liver. FGF-21 has recently been shown to have beneficial effects on a variety of metabolic parameters, including glucose and lipid metabolism and insulin sensitivity in animal models and is thought to exert potent antidiabetic and lipid-lowering agent of obesity and type 2 diabetes mellitus. FGF-21 activity depends on membrane protein beta Klotho that physically complexes with various FGF receptors, thus conferring them the ability to bind FGF-21 and activate downstream signaling pathways. Recombinant human FGF-21 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. | | | Catalog # | F4212-93D | | Endotoxin Level | 1.0 EU per 1ug of protein (determined by LAL method) | | AA Sequence | MGSSHHHHHH SSGLVPRGSH MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK | | TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPAPPEP PGILAPQPPD | | VGSSDPLSMV GPSQGRSPSY AS | | Storage and Stability | For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 21.6kD | | Source | E. coli | | Purity | 90% (SDS-PAGE) | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0, 10% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
