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You are here:Home » Antibodies » Abs to Receptors » Anti -Fibroblast Growth Factor Receptor 1 (FGFR1)

Anti -Fibroblast Growth Factor Receptor 1 (FGFR1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH
FGFR1 (Fibroblast Growth Factor Receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is a widely expressed membrane receptor, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM.
Catalog #F4305-02E
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1ug/ml recognizes 10ng recombinant bacterial, bacoluviral or native FGFR1.
Immunoprecipitation: Native, nuclear, recombinant and ligand-labeled FGFR1.
Immunohistochemistry: Frozen and paraffin sections.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No8k229
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4. No preservative added.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant human ectodomain of FGFR1a expressed in E. coli beginning with Pro23; antigen contained NH2-terminal Gly-Ser-Pro-Gly-Ile and COOH-terminal Glu-Phe sequences.
SpecificityRecognizes the alpha isoform of human Fibroblast Growth Factor Receptor 1. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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