Anti -Fibroblast Growth Factor Receptor 1 (FGFR1, Basic Fibroblast Growth Factor Receptor
1, BFGFR, bFGF-R, CD331, CEK, c-fgr, FGFBR, FGFR-1, FLG, FLJ99988, FLT2, Fms-like Tyrosine
Kinase 2, H2, H3, H4, H5, HBGFR, KAL2, N-SAM, OGD)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IH FC |
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| FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is a widely expressed membrane receptor, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM. | | | Catalog # | F4305-02G | | Applications | Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Flow Cytometry: 1:100 | | Western Blot: 1ug/ml. Recognizes 10ng recombinant bacterial, baculo-viral, or native FGFR1. FGFR1 is often seen as a doublet at ~110-120kD. | | Immunoprecipitation: Native, recombinant and ligand-labeled FGFR1. | | Immunohistochemistry (Paraffin): Paraformaldehyde fixed cells. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | N/A | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 8k231 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4. No preservative added. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant human ectodomain of FGFR1b expressed in E. coli beginning with proline 23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences. Cellular Localization: Cell membrane. | | Specificity | Recognizes alpha and beta isoforms of human Fibroblast Growth Factor Receptor 1. Epitope: Within the NH2-terminus of Ig loop II sequence lys145 and glu159 between the acidic box and heparin-binding sequence of FGFR1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Fibroblast Growth Factor Receptor 1 (FGFR1, Basic Fibroblast Growth Factor Receptor 1, BFGFR, bFGF-R, CD331, CEK, c-fgr, FGFBR, FGFR-1, FLG, FLJ99988, FLT2, Fms-like Tyrosine Kinase 2, H2, H3, H4, H5, HBGFR, KAL2, N-SAM, OGD) |
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