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You are here:Home » Antibodies » Abs to Membrane Proteins » Anti -Fibulin 5 (FBLN5, ARMD3, Developmental Arteries and Neural Crest Epidermal Growth Factor-like, DANCE, EVEC, FLJ90059, Urine p50 Protein, UP50)

Anti -Fibulin 5 (FBLN5, ARMD3, Developmental Arteries and Neural Crest Epidermal Growth
Factor-like, DANCE, EVEC, FLJ90059, Urine p50 Protein, UP50)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
Fibulin 5 is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries, but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, Fibulin-5 may play a role in vascular development and remodeling. Defects in Fibulin-5 are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3) (1).
Catalog #F4350-36
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No10J102
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues in human Fibulin 5.
SpecificityRecognizes human Fibulin 5 at ~50kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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