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You are here:Home » Biochemicals » Biochem-Drugs/Analogues » Fingolimod Hydrochloride (FTY-720A, FTY720, D04187, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Hydrochloride)

Fingolimod Hydrochloride (FTY-720A, FTY720, D04187,
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Hydrochloride)

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Specifications

Fingolimod (FTY720), a sphingosine 1-phosphate (S1P) analog, is a novel immunosuppressant drug that induces lymphopenia by preventing emergence of lymphocytes from lymph nodes. Fingolimod is a sphingosine-1-phosphate receptor 1 modulator and is in phase III clinical trials for relapsing-remitting multiple sclerosis.
Catalog #F4513-40
SolubilitySoluble in DMSO at 100mg/ml; soluble in ethanol at 100mg/ml; very poorly soluble in water. Up to 25ul of a solution of 13.8mg/ml (40mM) F4513-40 in 100% DMSO can be diluted into 5ml of plain water without precipitation, giving a final concentration of 200uM. In contrast, even a 1:1000 dilution of the same 13.8mg/ml DMSO stock solution into 10mM PBS, pH 7 results in a precipitate. Thus, F4513-40 solubility in PBS is likely to be well below 100uM, perhaps as low as 1-10ug/ml. Either DMSO, ethanol or plain water should be used as the solvent until the final dilution is made into culture medium
Elemental AnalysisCalculated:
C=66.35%
H=9.96%
Cl=10.31%
N=4.07%
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number162359-56-0
Molecular FormulaC19H33NO2•HCl
Molecular Weight343.93
Purity
HPLC~98%
TLC~98%
FormSupplied as a white powder
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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