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Fingolimod Hydrochloride (FTY-720A, FTY720, D04187, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Hydrochloride)
Fingolimod Hydrochloride (FTY-720A, FTY720, D04187,
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Hydrochloride)
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| Fingolimod (FTY720), a sphingosine 1-phosphate (S1P) analog, is a novel immunosuppressant drug that induces lymphopenia by preventing emergence of lymphocytes from lymph nodes. Fingolimod is a sphingosine-1-phosphate receptor 1 modulator and is in phase III clinical trials for relapsing-remitting multiple sclerosis. | | | Catalog # | F4513-40 | | Solubility | Soluble in DMSO at 100mg/ml; soluble in ethanol at 100mg/ml; very poorly soluble in water. Up to 25ul of a solution of 13.8mg/ml (40mM) F4513-40 in 100% DMSO can be diluted into 5ml of plain water without precipitation, giving a final concentration of 200uM. In contrast, even a 1:1000 dilution of the same 13.8mg/ml DMSO stock solution into 10mM PBS, pH 7 results in a precipitate. Thus, F4513-40 solubility in PBS is likely to be well below 100uM, perhaps as low as 1-10ug/ml. Either DMSO, ethanol or plain water should be used as the solvent until the final dilution is made into culture medium | | Elemental Analysis | Calculated: | | C=66.35% | | H=9.96% | | Cl=10.31% | | N=4.07% | | Storage and Stability | May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. | | CAS Number | 162359-56-0 | | Molecular Formula | C19H33NO2•HCl | | Molecular Weight | 343.93 | | Purity | | | HPLC | ~98% | | TLC | ~98% | | Form | Supplied as a white powder | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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