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You are here:Home » Biochemicals » Biochem-Drugs/Analogues » FK-506 (Fujimycin, Tacrolimus)

FK-506 (Fujimycin, Tacrolimus)


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FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein-12 (FKBP12). The resulting complex, in turn, interferes with calcineurin substrate interaction.
Catalog #F4522-01
SolubilitySoluble in DMSO at 100mg/ml; soluble in ethanol at 100mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Melting Point122-126ºC
Elemental AnalysisCalculated:
C: 64.57%
H: 8.69%
N: 1.71%
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 12 month. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number104987-11-3
Molecular FormulaC44H69NO12
Molecular Weight804.02
FormSupplied as a white powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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