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Anti -Flk-1 Receptor Tyrosine Kinase (KDR, VEGFR2) (Biotin)
Anti -Flk-1 Receptor Tyrosine Kinase (KDR, VEGFR2) (Biotin)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Purified |
E |
|
| Embryonic vascular system undergoes a series of complex, highly regulated series of events involving differentiation, migration and association of primitive endothelial cells. This process is termed vasculogenesis. A further remodeling of the primitive vascular system forms the mature cardiovascular system. Study of tumor angiogenesis has led to the identification of several proteins including basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF). VEGF acts by interacting with a family of largely endothelial-specific receptor tyrosine kinases that includes VEGFR-1 (flt-1 or fms-like tyrosine kinase 1), VEGFR-2 (flk-1 or fetal liver kinase-1/KDR or Kinase insert domain containing receptor), and VEGFR-3/Flt-4. Disruption of VEGFRs interferes with differentiation of endothelial cells and it is lethal for the embryo. FLK-1 (Fetal-Liver Kinase 1) a putative receptor protein tyrosine kinase. FLK-1 belongs to the family of type-1 membrane protein. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. It is expressed in endothelial cells of developing embryo (1). It is also expressed at high levels in adult heart, lung, kidney, brain and skeletal muscle, but is also expressed at lower levels in most other adult tissues. | | | Catalog # | F4565-08E | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilutions | ELISA: 1:5000-1:50,000; using 50-100ng of control peptide/well. | | Optimal dilutions to be determined by researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 7C29 | | Host | Rat | | Source | Mouse | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in 100mM Tris, pH 7.5, 0.2% BSA, 0.05% sodium azide, before the addition of glycerol to 40%. Labeled with Biotin. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant mouse FLK-1/VEGFR2 EC domain (20-762aa) | | Specificity | Recognizes mouse FLK13-Mb. Reacts specifically with human FLK-1/VEGFR-2/KDR. No crossreactivity with VGFR-1/FLT-1 or FLT-4. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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