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You are here:Home » Antibodies » Antibodies-Receptors, Tyrosine Kinase » Anti -Flk-1 Receptor Tyrosine Kinase (KDR, VEGFR2) (Biotin)

Anti -Flk-1 Receptor Tyrosine Kinase (KDR, VEGFR2) (Biotin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E
Embryonic vascular system undergoes a series of complex, highly regulated series of events involving differentiation, migration and association of primitive endothelial cells. This process is termed vasculogenesis. A further remodeling of the primitive vascular system forms the mature cardiovascular system. Study of tumor angiogenesis has led to the identification of several proteins including basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF). VEGF acts by interacting with a family of largely endothelial-specific receptor tyrosine kinases that includes VEGFR-1 (flt-1 or fms-like tyrosine kinase 1), VEGFR-2 (flk-1 or fetal liver kinase-1/KDR or Kinase insert domain containing receptor), and VEGFR-3/Flt-4. Disruption of VEGFRs interferes with differentiation of endothelial cells and it is lethal for the embryo. FLK-1 (Fetal-Liver Kinase 1) a putative receptor protein tyrosine kinase. FLK-1 belongs to the family of type-1 membrane protein. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. It is expressed in endothelial cells of developing embryo (1). It is also expressed at high levels in adult heart, lung, kidney, brain and skeletal muscle, but is also expressed at lower levels in most other adult tissues.
Catalog #F4565-08E
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionsELISA: 1:10,000-1:100,000; using 50-100ng of control peptide/well.
Optimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No7C29
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 100mM Tris, pH 7.5, 0.2% BSA, 0.05% sodium azide. Labeled with Biotin.
PurityPurified
ImmunogenRecombinant human Flk-1.
SpecificityRecognizes human human Flk-1. Does not recognize FLT-1 or FLT-4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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