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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -Flk-1 Receptor Tyrosine Kinase (KDR, VEGFR2)

Anti -Flk-1 Receptor Tyrosine Kinase (KDR, VEGFR2)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
The vascular endothelial growth factor receptor-2 (VRGFR-2), also known as kinase insert domain-containing receptor (KDR) or kinase insert domain-containing receptor /fetal liver kinase-1 (Flk1), is a tyrosine kinase receptor constitutively expressed in endothelial cells, which mediates proliferative, differentiation, survival signals and modulating developmental angiogenesis through interaction with VEGF (1-2). Upon binding to VEGF, VEGFR2 undergoes ligand-induced dimerization and oligomerization, which activate its intrinsic tyrosine kinase activity resulting in auto- and trans-phosphorylation on specific tyrosine residues in the cytoplasmic domain (3). Activation by VEGF leads to the activation of stress-activated protein kinase (SAPK) 2/p38 while activation by TNF results in the formation of Etk/VEGFR2 complex and activation of the PI3-K/AKT signaling pathway (4-5).
Catalog #F4565-09B
ApplicationsSuitable for use in Western Blotting. Other applications not tested.
Recommended DilutionWestern Blotting: 1:10-1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No6k178
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid.
PuritySupernatant
ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human VEGFR2.
SpecificityRecognizes human VEGFR2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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