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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -Flt1 (Fms-like Tyrosine Kinase 1, Vascular Endothelial Growth Factor Receptor 1, VEGF R1)

Anti -Flt1 (Fms-like Tyrosine Kinase 1, Vascular Endothelial Growth Factor Receptor 1,
VEGF R1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Flt-1 (human 1338aa, rat 1336aa and mouse 1330aa), a putative receptor protein tyrosine kinase, is a receptor for VEGF and PLGF. Flt-1 (fms-like tyrosine kinase-1) is a member of the flt family of receptor tyrosine kinases that also includes KDR/flk-1 and flt-4. The flt family encodes receptors for VEGF (vascular endothelial growth factor) that are characterized by seven Ig-like loops within their extracellular domain and a split kinase domain within the cytoplasmic domain. VEGF is an important angiogenic factor of many solid tumors and is also involved in the differentiation of endothelial cells. It has been reported that flt-1 receptor dimerization precedes phosphorylation after VEGF binding. Flt-1 has also been described as VEGFR1 and Flk-2. It is type 1 membrane protein and is expressed in normal lung, placenta, liver, kidney, heart, and brain but not in tumor cells.
Catalog #F4599-03B
ApplicationsSuitable for use in Western Blot. Not recommended for Immunoprecipitation. Other applications not tested.
Recommended DilutionsWestern Blot: 0.5-2ug/ml Detected Flt1 in human umbilical vein endothelium (HUVEC) membrane preps.
Optimal dilutions to be determined by the researcher.
Recommended Secondary AntibodiesI1904-06C: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo
I1904-06H: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No5H17
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide, 30% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenGST fusion protein corresponding to aa1251-1338 of human Flt1.
SpecificityRecognizes human Flt1, Mr ~180kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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