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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -Flt1 (Fms-like Tyrosine Kinase 1, Vascular Endothelial Growth Factor Receptor 1, VEGF R1)

Anti -Flt1 (Fms-like Tyrosine Kinase 1, Vascular Endothelial Growth Factor Receptor 1,
VEGF R1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Human Flt-1 is a type I transmembrane receptor for the angiogenic cytokine, VEGF. Alternate splicings of human VEGF R1 mRNA encode soluble, secreted isoforms that can function as inhibitors of VEGF. One, designated sFLT1-14 or sFLT1-e15a, encodes a 733aa, 95-135kD form that is produced by non-endothelial cells, notably by degenerative syncytiotrophoblasts within syncytial knots in the placenta. This form appears to be unique to primates and is produced in excess during preeclampsia of pregnancy. The peptide used as an immunogen is not present within either the full-length or alternate secreted forms of the protein.
Catalog #F4599-03G
ApplicationsSuitable for use in Western Blot and Direct ELISA. Other applications not tested.
Recommended DilutionsWestern Blot: 2ug/ml using human serum (preeclampsia)
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2B
Clone No11n72
HostMouse
SourceHuman
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa706-721 in human Flt1 (Accession #ACA62948).
SpecificityRecognizes human Flt1. In Direct ELISA and Western Blot there is no crossreactivity with recombinant mouse VEGF R1, recombinant human VEGFR1, VEGF R2, or recombinant human VEGF R3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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