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You are here:Home » Antibodies » Abs to Transport Proteins » Anti -Folate Transporter (RFC, Reduced Folate Carrier)

Anti -Folate Transporter (RFC, Reduced Folate Carrier)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
A sodium-dependent transport system is responsible for transfer and distribution of vitamins to different parts of the body, the transfer includes vitamins like pantothenate, biotin, and ascorbic acid etc, These transporters belong to Solute Carrier family (SLC). Since vitamins are required for essential metabolic processes in all mammalian cells, such cells have developed intrinsic mechanisms to active accumulation of essential vitamins. Thus transporters help these cells to fulfill their requirement, they include Sodium-dependent Multi-Vitamin Transporter (SMVT), Sodium-dependent Vitamin-C Transporter (SVCT) 1 & 2, Creatine Transporter (CRT1/ CT1). The other vitamin transporters from SLC family include Thiamine Transporter Protein 1 (THTR1), Folate Transporter or Reduced Folate Carrier 1 (RFC1), Thyroid Iodide Transporter (TIT) and Taurine Transporter (TAU) etc.
Folate Transporter/ FOLT/ RFC, a 512aa each protein in mouse and rat, 591aa in human (chrm 21q22.3, gene SLC19A1) transports folate compounds into mammalian cells via receptor mediated or carrier mediated mechanisms, as such maintains the intracellular concentration of folate. It shows 65% identity to mouse and hamster folate transporters.
Catalog #F5753-40
ApplicationsWestern Blot: 1-10ug/ml using ECL technique.
ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml (See F5753-40A).
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
Immunogen20aa peptide from rat RFC. Location
SpecificityRecognizes rat RFC.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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