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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified IH

Follicular dendritic cells (FDC) are cells of the immune system found in lymph follicles of secondary lymphoid organs and tertiary lymphoid organs. They are probably not of hematopoietic origin, though they look similar to true dendritic cells due to their filiform dendritic processes, but are of stromal, mesenchymal origin. The term FDC was introduced to distinguish them from other stromal cells localizing in the B cell follicles, the reticular fibroblast cells. FDCs are originally defined as cells within lymphoid follicles, which trap immune complexes. Their classification in MeSH. They assist in B cell maturation by the presentation of intact antigen to the B cells. This occurs in the germinal centers of peripheral lymphoid organs and induces class switching and proliferation.
Catalog #	F5923-51
Applications	Suitable for use in Immunohistochemistry (frozen and paraffin). Other applications not tested.
Recommended Dilution	Immunohistochemistry (frozen): 0.4ug/ml
	Immunohistochemistry (paraffin): 2ug/ml
	Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	10C265
Host	Mouse
Source	Human
Concentration	Not determined
Form	Supplied as a lyophilized powder from PBS, 0.01% Kathon, 5mg/ml BSA. Reconstitute with 500ul sterile 40-50% glycerol, ddH2O.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Enriched human blood dendritic cells
Specificity	Recognizes human Follicular Dendritic Cells.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.