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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -Formin Binding Protein 1-like, NT (C1orf39, FLJ20275, TOCA1, Toca-1, Transducer of Cdc42-dependent actin assembly protein 1)

Anti -Formin Binding Protein 1-like, NT (C1orf39, FLJ20275, TOCA1, Toca-1, Transducer of
Cdc42-dependent actin assembly protein 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N- WASP and Cdc42 and is essential for Cdc42- and PIP2- induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex (1). Decreased expression of TOCA- 1 significantly enhances neurite elongation in PC-12 cells; its overexpression in the same cells suppresses neurite elongation (2). It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain (2). Multiple isoforms of TOCA-1 are known to exist.
Catalog #F6002-63
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 15aa from near the amino terminus of the human TOCA-1 (GenBank accession no. NP_001020119).
SpecificityRecognizes human TOCA-1. Species crossreactivity: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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