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You are here:Home » Biochemicals » Biochem-Fine Chemicals » Forskolin (7b-Acetoxy-8,13-epoxy-1a,6b,9a-trihydroxy- labd-14-ene-11-one, Colforsin)

Forskolin (7b-Acetoxy-8,13-epoxy-1a,6b,9a-trihydroxy- labd-14-ene-11-one, Colforsin)

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Specifications

Forskolin is a powerful activator of adenyklate cyclase, resulting in an increase of intracellular cAMP concentration.1,2 Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP. Widely used tool for the investigation of the role of cAMP as a second messenger with a broad range of potential therapeutic applications. Inotropic agent and vasodilator. Induces platelet aggregation. Inhibits ion channels by a mechanism that does not involve cAMP. Non-competitive inhibitor of nicotinic acetylcholine receptors.
Catalog #F6024
Purity 99% TLC (NP, DCM, methanol 95:5)
99% TLC (RP C18, methanol, H2O 9:1)
Detection, spray with H2SO4 and heat
StabilityLight sensitive
Melting Point 228-230°C
Specific Rotation-26.19º
SolubilitySolubility (10mg/ml Ethyl acetate): Clear, colorless solution. Soluble in ethanol, chloroform and DMSO.
Note: Various solvents including ethanol, inhibited the forskolin activation of adenylate cyclase. Recommended to use DMSO at concentrations of < 5%.
Storage and Stability Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number66575-29-9
Molecular FormulaC22H34O7
Molecular Weight410.5
SourceColeus forskohlii
Purity99% TLC (NP, DCM, methanol 95:5)
99% TLC (RP C18, methanol, H2O 91) Detection, spray with H2SO4 and heat
FormSupplied as a white to off-white crystalline powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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