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You are here:Home » Antibodies » Antibodies-RNA Binding Proteins » Anti -Fragile X Mental Retardation Protein 1 (FMR1, FMR-1, FMRP, FRAXA, MGC87458, POF, POF1, Protein FMR-1)

Anti -Fragile X Mental Retardation Protein 1 (FMR1, FMR-1, FMRP, FRAXA, MGC87458, POF,
POF1, Protein FMR-1)


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Clone Host Grade Applications
Monoclonal Mouse Ascites E B IH IC
Fragile X Mental Retardation Protein (FMRP) is an RNA-Binding protein that is associated to polysomes and may be involved in the transpot of mRNA from the nucleus to the cytoplasm. Defects in FMR1 are the cause of Fragile X syndrome, which is a common genetic disease characterized by moderate to severe mental retardation, macroorchidism, large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplication of a CGG repeat regions with is directly in front of the coding region.
Catalog #F6072
ApplicationsSuitable for use in Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry and the detection of FMRP on blood smears. Other applications have not been tested.
Recommended DilutionsWestern Blot: 1:500 detected FMRP on 10ug of mouse E17 spinal cord lysate. Lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with F6072. Proteins were visualized using an IgG (HRP) goat anti-mouse and a chemiluminescence detection system.
ELISA: 1:500-1:5000
Immunohistochemistry (Paraffin and Frozen): 1:500-1:5000
Immunocytochemistry: 1:500-1:5000 was used on transfected cells. Light fixation (2% PFA, permeabilize with 0.1% Triton in block only)
Detection of FMRP on Blood Smears: 1:500-1:5000
Optimal dilutions to be determined by the researcher.
Positive ControlHeLa whole cell lysatre, HeLa nuclear lysate, mouse E17 spinal cord lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
Clone No2Q53
ConcentrationNot Determined
FormSupplied as a liquid. No preservatives added.
ImmunogenFusion protein with a full length human FMRP.
SpecificityRecognizes human FMRP at ~71kD. The epitope is localized in the N-terminal half of FMRP. Crossreaction with FXR protein may be detected in cases of high expression of the latter proteins.
Species CrossreactivityMouse and rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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