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You are here:Home » Antibodies » Abs to RNA Binding Proteins » Anti -FMR1 (Fragile X Mental Retardation 1 Protein, Protein FMR-1, FMRP)

Anti -FMR1 (Fragile X Mental Retardation 1 Protein, Protein FMR-1, FMRP)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression. RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
Catalog #F6072-10F
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 0.3-1ug/ml, observed in lysates of cell lines HeLa, Jurkat and Kelly on ~70kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-NPNKPATKDTFHKIK, from human FMR1, at the internal region of the protein (NP_002015.1).
SpecificityRecognizes human FMR1. Species sequence homology: Rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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