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You are here:Home » Antibodies » Abs to Wnt Proteins » Anti -Frizzled 4 (Frizzled Family Receptor 4, Frizzled-4, Fz-4, FZD4, FZD4S, FzE4, hFz4, CD344, EVR1, FEVR, MGC34390)

Anti -Frizzled 4 (Frizzled Family Receptor 4, Frizzled-4, Fz-4, FZD4, FZD4S, FzE4, hFz4,
CD344, EVR1, FEVR, MGC34390)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
FZD4 is a Frizzled Receptor involved in mediating Wnt signaling. A splicing variant of frizzled-4, FZD4s, encodes a soluble-type positive regulator of the Wnt signaling pathway. Mutations in FZD4 are associated with retinal angiogenesis. FZD4 is widely expressed, particularly in heart, skeletal muscle, ovary, and fetal kidney. Transcripts have also been identified in liver, kidney, pancreas, spleen, and fetal lung, and in smaller amounts in placenta, adult lung, prostate, testis, colon, and fetal brain. FZD4 expression has not been reported in several cancer cell lines studied. ESTs have been isolated from adipose, adrenal, B-cell/lung/testis, bone marrow, brain, breast, colon, embryo, gallbladder, head/neck, heart, heart/melanocyte/uterus, kidney, liver, liver/spleen, lung, placenta, prostate, skeletal muscle, skin, and vessel libraries.
Catalog #F6401-16E
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 25ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman Kidney
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the C-terminal domain of human FZD4.
SpecificityRecognizes rat FZD4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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