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You are here:Home » Antibodies » Antibodies-Wnt Proteins » Anti -Frizzled 7 (Frizzled-7, Frizzled (Drosophila) Homolog of 7, Frizzled Homolog 7, Fz 7, Fz-7, FZD7, FzE3, hFz7, Homolog of Drosophila Frizzled 7)

Anti -Frizzled 7 (Frizzled-7, Frizzled (Drosophila) Homolog of 7, Frizzled Homolog 7, Fz
7, Fz-7, FZD7, FzE3, hFz7, Homolog of Drosophila Frizzled 7)


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Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
Suitable for use in Peptide ELISA and Western Blot. Other applications not tested.
Catalog #F6401-30A
Recommended DilutionsPeptide ELISA: Antibody detection limit dilution 1:64,000.
Western Blot: 0.3-1ug/ml; Approx 60kD band observed in lysates of cell lines HEK293 and HepG2 (calculated MW of 63.6kD according to NP_003498).
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in Tris-saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-RFYHRLSHSSKGET of the C Terminus of human Frizzled 7 (NP_003498).
SpecificityRecognizes human Frizzled 7 at ~63kD. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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