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Abs to Wnt Proteins
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Anti -Frizzled 7 (Frizzled-7, Frizzled (Drosophila) Homolog of 7, Frizzled Homolog 7, Fz 7, Fz-7, FZD7, FzE3, hFz7, Homolog of Drosophila Frizzled 7) (BSA Free)
Anti -Frizzled 7 (Frizzled-7, Frizzled (Drosophila) Homolog of 7, Frizzled Homolog 7, Fz
7, Fz-7, FZD7, FzE3, hFz7, Homolog of Drosophila Frizzled 7) (BSA Free)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. | | | | | | Applications: | | | Suitable for use in Peptide ELISA and Western Blot. Other applications not tested. | | | Catalog # | F6401-30A1 | | Recommended Dilution | Peptide ELISA: Antibody detection limit dilution 1:64,000. | | Western Blot: 0.3-1ug/ml; Approx 60kD band observed in lysates of cell lines HEK293 and HepG2 (calculated MW of 63.6kD according to NP_003498.1). | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. BSA free. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Peptide with sequence C-RFYHRLSHSSKGET, from the C Terminus of the protein sequence according to NP_003498.1 | | Specificity | Recognizes human Frizzled 7 at ~63kD. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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