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You are here:Home » Antibodies » Abs to Wnt Proteins » Anti -Frizzled 7 (Frizzled-7, Frizzled (Drosophila) Homolog of 7, Frizzled Homolog 7, Fz 7, Fz-7, FZD7, FzE3, hFz7, Homolog of Drosophila Frizzled 7) (BSA Free)

Anti -Frizzled 7 (Frizzled-7, Frizzled (Drosophila) Homolog of 7, Frizzled Homolog 7, Fz
7, Fz-7, FZD7, FzE3, hFz7, Homolog of Drosophila Frizzled 7) (BSA Free)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
Applications:
Suitable for use in Peptide ELISA and Western Blot. Other applications not tested.
Catalog #F6401-30A1
Recommended DilutionPeptide ELISA: Antibody detection limit dilution 1:64,000.
Western Blot: 0.3-1ug/ml; Approx 60kD band observed in lysates of cell lines HEK293 and HepG2 (calculated MW of 63.6kD according to NP_003498.1).
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide. BSA free.
PurityPurified by immunoaffinity chromatography.
ImmunogenPeptide with sequence C-RFYHRLSHSSKGET, from the C Terminus of the protein sequence according to NP_003498.1
SpecificityRecognizes human Frizzled 7 at ~63kD. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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