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You are here:Home » Antibodies » Abs to Wnt Proteins » Anti -Frizzled 7 (FZD7, Fz-7, hFz7, FzE3, Frizzled-7)

Anti -Frizzled 7 (FZD7, Fz-7, hFz7, FzE3, Frizzled-7)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
FZD7, a 574aa protein, is a novel member of 'Frizzled' gene family. These proteins act as transmembrane receptors for Wnt signaling proteins. FZD7 contains an N-terminal signaling sequence, a cysteine-rich extracellular domain, 7 putative transmembrane domains and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 participates in cell proliferation through activation of Wnt-beta catenin-TCF pathway. FZD7 gene expression may down-regulate APC function and enhance beta catenin-mediated signals to up-regulate genes associated with cell proliferation in human esophageal carcinomas. Northern Blot analysis detected a ubiquitous expression of FZD7 with high expression in skeletal muscle and fetal kidney.
Catalog #F6401-30E
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa1-12 [MRGPGTAASHSPC] of mouse Fz7.
SpecificityRecognizes mouse FZD7. Species sequence homology: rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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