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Abs to Wnt Proteins
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Anti -Frizzled 7 (FZD7, Fz-7, hFz7, FzE3, Frizzled-7)
Anti -Frizzled 7 (FZD7, Fz-7, hFz7, FzE3, Frizzled-7)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| FZD7, a 574aa protein, is a novel member of 'Frizzled' gene family. These proteins act as transmembrane receptors for Wnt signaling proteins. FZD7 contains an N-terminal signaling sequence, a cysteine-rich extracellular domain, 7 putative transmembrane domains and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 participates in cell proliferation through activation of Wnt-beta catenin-TCF pathway. FZD7 gene expression may down-regulate APC function and enhance beta catenin-mediated signals to up-regulate genes associated with cell proliferation in human esophageal carcinomas. Northern Blot analysis detected a ubiquitous expression of FZD7 with high expression in skeletal muscle and fetal kidney. | | | Catalog # | F6401-30E | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa1-12 [MRGPGTAASHSPC] of mouse Fz7. | | Specificity | Recognizes mouse FZD7. Species sequence homology: rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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