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You are here:Home » Antibodies » Abs to Wnt Proteins » Anti -Frizzled 7 (FZD7, Fz-7, hFz7, FzE3, Frizzled-7)

Anti -Frizzled 7 (FZD7, Fz-7, hFz7, FzE3, Frizzled-7)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
FZD7, a 574aa protein, is a novel member of 'Frizzled' gene family. These proteins act as transmembrane receptors for Wnt signaling proteins. FZD7 contains an N-terminal signaling sequence, a cysteine-rich extracellular domain, 7 putative transmembrane domains and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 participates in cell proliferation through activation of Wnt-beta catenin-TCF pathway. FZD7 gene expression may down-regulate APC function and enhance beta catenin-mediated signals to up-regulate genes associated with cell proliferation in human esophageal carcinomas. Northern Blot analysis detected a ubiquitous expression of FZD7 with high expression in skeletal muscle and fetal kidney.
Catalog #F6401-30F
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.3-1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHepG2 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-RFYHRLSHSSKGET, from the C-terminus of the protein sequence according to NP_003498.1.
SpecificityRecognizes human Frizzled 7. Species sequence homology: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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